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目的:观察氨酚羟考酮片对中重度癌痛患者的临床镇痛效果和不良反应。方法:选择53例中重度癌痛患者应用氨酚羟考酮片,分为中度癌痛组和重度癌痛组,观察其疗效、剂量及不良反应。结果:中度癌痛组和重度癌痛组的总有效率均达100%,但重度癌痛组氨酚羟考酮片的治疗剂量较中度癌痛组大,并具有显著性差异(P<0.05)。其主要不良反应头晕、恶心、呕吐、便秘,经对症治疗缓解。结论:氨酚羟考酮片治疗中晚期癌症疼痛疗效确切,且不良反应小,临床上可作为中重度癌痛患者首选的三阶梯止痛用药。
Objective: To observe the clinical analgesic effects and adverse reactions of oxycodone tablets in patients with moderate to severe cancer pain. Methods: 53 patients with moderate-to-severe cancer pain were selected and treated with oxycodone oxycodone tablets. The patients were divided into moderate cancer pain group and severe cancer pain group. The curative effect, dose and adverse reaction were observed. Results: The total effective rate was 100% in the moderate cancer pain group and the severe cancer pain group, but the treatment dose of acetaminophen tablet in the severe cancer pain group was larger than that in the moderate cancer pain group, and had significant difference (P <0.05). The main side effects of dizziness, nausea, vomiting, constipation, symptomatic treatment to ease. Conclusion: Oxycodone tablets of paracetamol treatment of advanced cancer pain curative effect is accurate, and the adverse reaction is small, clinically as the preferred three-stage pain relief in patients with moderate to severe cancer pain medication.