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普罗帕酮(Propafenone,心律平)是一种具有膜稳定性或局麻作用的高效抗心律失常新药,按电生理分类属Ic类。该药直接作用于细胞膜,通过调节钠通道的快速内流,降低心肌细胞跨膜电位最大上升速率,轻度延长动作电位时间和有效不应期,提高阈电位。适应于治疗室性、室上性异位搏动,室性以及室上性心动过速、预激综合征等。我院内科自1986年以来,采用国产普罗帕酮(广州明兴制药厂生产)片剂治疗心律失常40例,现将其临床观察情况报告如下:
Propafenone (Propafenone) is a new anti-arrhythmic drug with high membrane antidegradability or local anesthetic action. It is classified as Class Ic by electrophysiology. The drug directly on the cell membrane, by regulating the rapid influx of sodium channels, reducing the maximum rate of myocardial cell transmembrane potential rise, slightly prolong the action potential time and effective refractory period, and increase the threshold potential. Adapt to the treatment of ventricular, supraventricular ectopic beats, ventricular and supraventricular tachycardia, pre-excitation syndrome. Our hospital internal medicine since 1986, the use of domestic propafenone (Guangzhou Ming Hing Pharmaceutical Factory) tablet treatment of arrhythmia 40 cases, now the clinical observation of the report as follows: