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目的探讨早期药物联合心理干预对脑卒中后抑郁症状和神经功能恢复的影响。方法选取80例脑卒中后抑郁患者,经汉密顿抑郁量表(HAMD-17)评分≥8分,随机分成治疗组和对照组各40例,两组均予脑卒中常规治疗和康复训练,治疗组在此基础上加用药物(帕罗西汀)并联合心理干预治疗。在治疗前、治疗后2、4、8周分别对患者行HAMD-17和神经功能缺损程度(SSS)评分。结果治疗后4、8周治疗组患者HAMD-17和SSS评分明显优于对照组(P<0.01)。抑郁症状和神经功能临床疗效治疗组明显优于对照组(P<0.01或P<0.05)。结论早期药物联合心理干预可明显改善脑卒中后抑郁程度,并能促进神经功能恢复。
Objective To explore the effect of early drug combination psychological intervention on post-stroke depressive symptoms and neurological function recovery. Methods Eighty patients with post-stroke depression were randomly divided into treatment group (n = 40) and control group (n = 40) by HAMD-17 score. Both groups were given routine treatment and rehabilitation training for stroke, The treatment group on the basis of adding drugs (paroxetine) and combined psychological intervention. Patients were treated with HAMD-17 and neurological deficit (SSS) scores before treatment and 2, 4, 8 weeks after treatment. Results The scores of HAMD-17 and SSS in treatment group were significantly better than those in control group 4 and 8 weeks after treatment (P <0.01). Depression symptoms and neurological clinical efficacy of the treatment group was significantly better than the control group (P <0.01 or P <0.05). Conclusion The combination of early drug and psychological intervention can significantly improve the degree of post-stroke depression and promote neurological recovery.