论文部分内容阅读
本文用Ｎ－甲基－Ｎ＇－硝基－Ｎ－亚硝基胍（ＭＮＮＧ）诱发大白鼠前胃鳞癌及癌前病变的病理形态学动态观察，结果表明，～４月组前胃粘膜开始增厚、粗糙，出现颗粒状结节和乳头状肿瘤，９个月以后乳头状肿瘤达３１．２％～８０．０％；前胃鳞癌的癌变起始基底细胞增生，继而向粘膜上皮表面、上皮内和间质内生长，转变成乳头状瘤为主的癌前病变，随后发生癌变，由早期癌发展为浸润癌。首例癌变和浸润癌见于第１７８天，诱癌率分别高达５８．３％（～１２月）、８６．７％（～１４月）、８６．７％（～２０月）．其中，乳头状瘤癌变３０例，原位癌１６例，浸润癌２１例。
In this paper, the pathomorphological changes of precancerous squamous cell carcinoma and precancerous lesions in rats induced by N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) were observed. Begin thickening, roughening, granular nodules and papillary tumors, 91.2 months later, papillary tumors 31.2% to 80.0%; cancerous basal cells of the prodromal squamous cell carcinoma proliferate, and then to the mucosal epithelium Surface, epithelial and interstitial growth, transformed into papilloma-dominated precancerous lesions, followed by cancer, from early cancer to invasive cancer. The first cases of cancerous and infiltrating cancers were seen on the 178th day, and the cancer-inducing rates were as high as 58.3% (~12 months), 86.7% (~14 months), and 86.7% (~20 months). Among them, there were 30 cases of papilloma carcinoma, 16 cases of carcinoma in situ, and 21 cases of invasive carcinoma.