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目的:研究天胡荽有效部位HS抗肝纤维化的作用。方法:复制猪血清所致的大鼠肝纤维化模型,设立空白对照组,模型对照组,γ干扰素组,HS高剂量组(1.5g/kg)与低剂量组(0.5g/kg),观察HS对丙氨酸氨基转移酶(ALT),门冬氨酸氨基转移酶(AST),白蛋白(Alb),总蛋白,羟脯氨酸(Hyp)的含量以及对肝脏病理形态学的影响。结果:HS显著降低大鼠血清中的ALT,AST水平以及肝组织中的Hyp水平;组织病理学结果显示:HS高,低剂量组大鼠肝组织纤维化程度都有一定改善。结论:HS具有良好的抗免疫型肝纤维化作用。
Objective: To study the anti-fibrosis effect of HS in the effective part of Rhizoma. METHODS: Rat hepatic fibrosis model induced by serum was duplicated. The control group, model control group, interferon-gamma group, high-dose HS group (1.5g/kg) and low-dose group (0.5g/kg) were established. Observe the effect of HS on alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (Alb), total protein, hydroxyproline (Hyp) and its effect on liver pathomorphology . RESULTS: HS significantly decreased ALT and AST levels in serum and Hyp levels in liver tissues. Histopathological results showed that the liver tissue fibrosis in HS rats with high and low doses was improved. Conclusion: HS has a good anti-immune liver fibrosis.