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目的评价阿奇霉素序贯疗法的疗效。方法 120例下呼吸道感染患者随机分为序贯组(61例)和静脉滴注组(59例)。d1～d3两组均静脉滴注阿奇霉素0.5g·次~(-1),qd。d4～d7,序贯组改为口服阿奇霉素颗粒0.5g·次~(-1),qd;静脉滴注组则继续静脉滴注。治疗前、后均作痰培养,X线胸片,血、尿常规,肝、肾功能检查;治疗过程中观察症状和体征变化。结果序贯组和静脉滴注组治疗下呼吸道感染有效率分别为89%和88%,细菌清除率分别为87%和86%,均无显著差异(P>0.05)。2组不良反应发生率均为5%,无显著差异(P>0.05)。结论阿奇霉素序贯疗法是一种安全、有效、经济、方便的治疗方法。
Objective To evaluate the efficacy of sequential therapy of azithromycin. Methods 120 cases of lower respiratory tract infection were randomly divided into sequential group (61 cases) and intravenous drip group (59 cases). d1 ~ d3 were intravenously administered azithromycin 0.5g · times ~ (-1), qd. d4 ~ d7, sequential group changed to oral azithromycin granules 0.5g · times ~ (-1), qd; intravenous drip group continued intravenous drip. Before and after treatment were sputum culture, X-ray, blood, urine routine, liver and kidney function tests; observation of symptoms and signs during treatment. Results The effective rates of sequential group and intravenous drip group in treatment of lower respiratory tract infection were 89% and 88% respectively, and the bacterial clearance rates were 87% and 86% respectively (P> 0.05). Adverse reactions in both groups were 5%, no significant difference (P> 0.05). Conclusion Sequential azithromycin therapy is a safe, effective, economical and convenient treatment.