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用极谱法和比色法分析环磷酰胺(下简称CP)及其制剂,乃依据CP 与亚硝酸的反应。用阴极扩散波作CP 的直流极谱测定,其准确度为99.98±1.09%。此波形良好,电极反应不可逆。通过差示脉冲极谱分析可测定由0至10ppm 的CP,当浓度在10～60ppm 时,总准确度为100.16±0.99%.同时利用柠檬黄色的亚硝基衍生物的吸收度与CP 浓度间的线性关系可进行比色分析,准确度为100.2±u.99%.
Polarography and colorimetric analysis of cyclophosphamide (hereinafter referred to as CP) and its preparation, is based on the reaction of CP and nitrite. The cathodic diffusion wave was used for the CP direct current polarographic determination with an accuracy of 99.98 ± 1.09%. This waveform is good, the electrode reaction is not reversible. The CP from 0 to 10 ppm can be determined by differential pulse polarography, with a total accuracy of 100.16 ± 0.99% at concentrations from 10 to 60 ppm.At the same time, the absorbance of the lemon-nitroso derivative and the CP concentration The linear relationship can be colorimetric analysis with an accuracy of 100.2 ± u.99%.