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目的:探讨抑癌基因P27kipl蛋白与癌基因P185蛋白联合标记在子宫内膜癌早期诊断中的价值。方法:采用S-P免疫组化方法对2008.1-2010.3月间我院收治的子宫内膜癌患者66例(癌症组),子宫非典型增生病变患者29例(增生组),并设立子宫内膜正常组织31例为对照组织进行检测。结果:癌症组P27kipl表达阳性率最低,组间比较差异有统计学意义(P<0.05);而对照组与增生组比较差异无统计学意义(P>0.05)。癌症组P185的表达与增生组比较差异有统计学意义(P<0.05);对照组与癌症组及增生组比较,差异均有统计学意义(均P<0.01)。结论:P27kipl蛋白与P185蛋白对肿瘤的发生和调控有重要作用,临床联合检测,对子宫内膜癌的诊断有积极意义。
Objective: To investigate the value of combination of P27kipl protein and oncogene P185 protein in the early diagnosis of endometrial carcinoma. Methods: SP method of immunohistochemistry in our hospital from January 2008 to January 2010 3 months in patients with endometrial cancer in 66 cases (cancer group), uterine atypical hyperplasia in 29 cases (hyperplasia group), and the establishment of endometrial normal tissue 31 cases of control tissues for testing. Results: The positive rate of P27kipl expression in cancer group was the lowest, with significant difference between the two groups (P <0.05). There was no significant difference between the control group and the proliferation group (P> 0.05). The expression of P185 in the cancer group was significantly different from that in the hyperplastic group (P <0.05). The difference between the control group and the cancer group and the hyperplastic group was statistically significant (both P <0.01). Conclusion: P27kipl protein and P185 protein play an important role in tumorigenesis and regulation. Combined detection of P27kipl protein and P185 protein has positive significance for the diagnosis of endometrial carcinoma.