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目的观察炉甘石敛口生肌的药效作用。方法建立深达肌层的大鼠小面积全层皮肤缺损创面模型,观察炉甘石对损伤修复中大鼠体质量、创面直径以及创面肉芽组织的影响。结果炉甘石有助于缩小创口面积;炉甘石、煅炉甘石在高剂量时均可以促进肉芽组织中的新生毛细血管生成(P<0.01),增加受损创面的血供,加速创面恢复。炉甘石高剂量组在给药8 d后,可以增大新生肉芽组织中毛细血管的面积(P<0.05);煅炉甘石高剂量组可以增加毛细血管的周长(P<0.01)。炉甘石、煅炉甘石均可增大肉芽组织中毛细血管管径和增加毛细血管的数量(P<0.01或P<0.05),对新生毛细血管的生长具有明显促进作用。结论炉甘石、煅炉甘石均能促进大鼠伤口成纤维细胞和毛细血管的形成,加快肉芽组织增生,从而加速皮肤创口的愈合,煅炉甘石生肌作用更强。
Objective To observe the pharmacodynamic effects of calamine on myogenic growth. Methods Deep partial myometrial defect model of full-thickness skin defect was established in rats. The effects of calamine on the body weight, wound diameter and wound granulation tissue were observed. Results The calamine could help to reduce the wound area. Both calamine and calcined calamine could promote the angiogenesis of granulation tissue (P <0.01) at high dose, increase the blood supply of impaired wound and accelerate wound healing restore. The calamine high dose group could increase the area of capillaries in nascent granulation tissue (P <0.05) after 8 d administration, and increase the capillary circumference (P <0.01) in calcined high dose calamine group. Both calamine and calcined kaolinite could increase the capillary diameter and increase the number of capillaries in granulation tissue (P <0.01 or P <0.05), which obviously promoted the growth of newborn capillaries. Conclusion Both calamine and calcined calamine can promote the formation of fibroblasts and capillaries in rat wounds, accelerate the proliferation of granulation tissue and accelerate the healing of skin wounds.