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目的:探讨4种中医本虚证候在蛋白尿患儿中的分布及中医辨证施治在蛋白尿患儿中的治疗价值。方法:收集临床符合脾气亏虚型、气阴两虚型、肝肾阴虚型及脾肾阳虚型4种本虚中医证型的56例蛋白尿患儿,比较4种中医本虚证候在蛋白尿患儿中的分布情况。所有病例再随机分为中西医结合组及西医组,观察两组蛋白尿患儿治疗后的中医证型转变情况。结果:在符合要求的56例病例中,气阴两虚型最多,共28例占50%;肝肾阴虚型19例,占33.9%;脾气亏虚型7例,占12.5%;脾肾阳虚型仅有2例,占3.6%。在疾病分布上,儿童蛋白尿则以肾病综合征为主,其次为过敏性紫癜肾炎,二者证型在儿童同样以气阴两虚型及肝肾阴虚型居多。中西医结合组治疗后有9例患儿的虚损证型消失,肝肾阴虚型病例较前稍增,但气虚型及气阴两虚型有明显减少,与治疗前相比存在统计学差异(P<0.05)。相对于治疗前,西医组肝肾阴虚型增多,脾气亏虚型及气阴两虚型稍减少,治疗前后无统计学差异。结论:儿童蛋白尿患儿以气阴两虚型及肝肾阴虚型居多,脾肾阳虚型少见;中药辨证施治则对蛋白尿患儿的虚损证候有较好的调理作用。
Objective: To investigate the distribution of four syndromes of TCM deficiency syndrome in patients with proteinuria and the therapeutic value of TCM syndrome differentiation in patients with proteinuria. Methods: Fifty-six patients with proteinuria were enrolled in this study. Four cases of proteinuria were enrolled in this study. Four patients with proteinuria were found to be deficiency of qi and yin, deficiency of qi and yin, deficiency of liver and kidney and deficiency of spleen and kidney, In the distribution of proteinuria in children. All cases were randomly divided into traditional Chinese and Western medicine group and Western medicine group, observed two groups of patients with proteinuria after treatment of TCM syndrome changes. Results: Among the 56 cases that meet the requirements, the most patients were qi and yin, 28 cases accounted for 50%, 19 cases were liver and kidney yin deficiency, accounting for 33.9%, 7 cases were deficiency of temper, accounting for 12.5% Yang deficiency type only 2 cases, accounting for 3.6%. In the distribution of disease, children with proteinuria nephrotic syndrome, followed by allergic purpura nephritis, the two syndromes in children with the same qi and yin deficiency type and liver and kidney yin deficiency type mostly. After the treatment of traditional Chinese and western medicine, 9 cases of children disappeared, the cases of liver-kidney yin deficiency were slightly increased, but the qi deficiency and qi-yin deficiency were significantly reduced, compared with the statistics before treatment Difference (P <0.05). Relative to the treatment, Western medicine group increased liver and kidney Yin, temper deficiency and Qi and Yin Deficiency type slightly reduced before and after treatment no significant difference. Conclusions: Children with proteinuria are predominant in qi and yin-deficiency type and liver-kidney-yin deficiency type, but rare in spleen and kidney yang deficiency syndrome. The treatment of syndrome differentiation by traditional Chinese medicine has a good conditioning effect on the patients with proteinuria.