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目的:探讨幽门螺旋杆菌(Hp)相关性十二指肠溃疡(DU)患者应用兰索拉唑与阿莫西林联合治疗的临床效果。方法:抽选2014年10月至2016年5月贵港市港北区人民医院收治的108例Hp检测为阳性的DU患者,随机分为两组,各组54例,对照组联合使用奥美拉唑与克拉霉素,观察组联合使用兰索拉唑与阿莫西林,观察两组治疗效果、Hp转阴时间,随访6个月统计复发率。结果:观察组治疗总有效率、Hp转阴时间及复发率均明显优于对照组,组间比较,差异具有统计学意义(P<0.05)。结论:兰索拉唑联合阿莫西林治疗Hp相关性DU疗效确切,可有效缩短Hp转阴时间,降低复发率。
Objective: To investigate the clinical effect of combination of lansoprazole and amoxicillin in patients with Helicobacter pylori (Hp) -related duodenal ulcer (DU). Methods: A total of 108 DU patients who were positive for Hp test were admitted to Hong Kong People’s Hospital of Guigang City from October 2014 to May 2016. They were randomly divided into two groups (n = 54 in each group). The control group was treated with omeprazole And clarithromycin, observation group combined lansoprazole and amoxicillin, the two groups were observed the therapeutic effect, Hp negative conversion time, followed up for 6 months statistical rate of recurrence. Results: The total effective rate of observation group, Hp negative conversion time and recurrence rate were significantly better than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion: Lansoprazole combined with amoxicillin treatment of Hp-related DU exact effect, can effectively shorten the Hp negative conversion time and reduce the recurrence rate.