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由于碳纳米管本身具有诸多优异的物理化学性质,已经在生物学和医学领域展现出潜在的应用前景.从纳米科技的长期发展而言,碳纳米管的安全应用及其潜在的毒理学评价显得非常重要.众所周知,碳纳米管用于载药、诊断或成像等生物医学领域时,会与生物体内的各种蛋白质产生相互作用,进而会改变碳纳米管自身的理化性质和影响蛋白质的构象及功能,从而引发不同的生物反应.而通过将蛋白质连接到碳纳米管上制备的生物器件,既降低了碳纳米管潜在毒性又为其安全生物应用开拓了市场.因此深入阐述碳纳米管-蛋白质相互作用的机制及后续的生物效应,对发展碳纳米管的安全应用具有重要意义.
Due to the many excellent physicochemical properties of carbon nanotubes themselves, potential applications have been demonstrated in the fields of biology and medicine.From the long-term development of nanotechnology, the safe application of carbon nanotubes and their potential toxicology evaluation Is very important.As we all know, carbon nanotubes for drug, diagnostic or imaging and other biomedical fields, it will interact with various proteins in the body, which will change the physical and chemical properties of carbon nanotubes and affect protein conformation and function , Thus triggering different biological reactions.Biological devices prepared by connecting proteins to carbon nanotubes not only reduce the potential toxicity of carbon nanotubes but also open up the market for their safe biological applications.Therefore, in-depth discussion of carbon nanotubes - protein mutual The mechanism of action and subsequent biological effects are of great significance for the development of safe application of carbon nanotubes.