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目的:研制20(S)-原人参二醇(Ppd)药质体和Brij78修饰的Ppd药质体并对其进行体外评价。方法:采用薄膜超声法制备Ppd药质体和Brij78修饰的Ppd药质体,用超速离心法测包封率,用动态光散射(DLS)考察粒径分布,以粒径和包封率为指标,分别考察温度、乙醇、酸碱和人工胃肠液等对药质体的影响。结果:薄膜超声法制备的Ppd药质体的包封率为(80.84±0.53)%,粒径100.1 nm;Brij78修饰的Ppd药质体的包封率为(72.76±0.63)%,粒径为117.3 nm。结论:该药质体制备工艺简单可行,制剂学性质较稳定。
OBJECTIVE: To develop 20 (S) - protopanaxadiol (Ppd) and Brij78 modified Ppd and evaluate its in vitro performance. Methods: Ppd and Brij78 modified Ppd were prepared by membrane ultrasonication. The entrapment efficiency was determined by ultracentrifugation. Particle size and entrapment efficiency were measured by dynamic light scattering (DLS) , Were investigated temperature, ethanol, acid and alkali and artificial gastrointestinal fluid on the impact of the body. Results: The encapsulation efficiency of Ppd was 80.84 ± 0.53% and the particle size was 100.1 nm. The encapsulation efficiency of Ppd was 72.76 ± 0.63% 117.3 nm. Conclusion: The preparation process of the drug is simple and feasible, the preparation of the nature of the more stable.