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目的：研究Ｂｃｌ－２蛋白产物在皮肤鳞状细胞癌（ＳＣＣ）中的表达及其意义。方法：应用Ｓ－Ｐ免疫组化方法检测。结果：１０例ＳＣＣ均表达Ｂｃｌ－２蛋白，而且肿瘤细胞Ｂｃｌ－２蛋白表达强度与表皮Ｂｃｌ－２蛋白表达强度及肿瘤Ｂｒｏｄｅｒ病理分级呈显著正相关（ｒ′ｓ分别为１和０．９１９，Ｐ分别＜０．００１）。结论：支持皮肤ＳＣＣ起源于表皮，表明Ｂｃｌ－２蛋白与皮肤ＳＣＣ的发生与发展密切相关。
Objective: To study the expression and significance of Bcl-2 protein product in cutaneous squamous cell carcinoma (SCC). METHODS: S-P immunohistochemistry was used for detection. RESULTS: Bcl-2 protein was expressed in 10 cases of SCC, and the expression of Bcl-2 protein was positively correlated with the expression of Bcl-2 protein in the epidermis and Broder’s pathological grade (r’s were 1 and 0.919, respectively). P <0.001 respectively). Conclusion: The skin-derived SCC originated from the epidermis, indicating that Bcl-2 protein is closely related to the occurrence and development of skin SCC.