【摘 要】
：
A series of cross-linked gels of Poly(N-isopropylacrylamide)[P(NIPAAm)]and Poly(methacr-ylic acid)[P(MAA)]homopolymers and P(NIPAAm-co-MAA)random copolymers were synthesized based on NIPAAm and MAA using 4,4-Bis-(methacryloylamino)azobenzene (BMAAB)as a c
【机 构】
：
School of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China;Department of Ph
【出 处】
：
武汉理工大学学报（材料科学版）（英文版）
论文部分内容阅读
A series of cross-linked gels of Poly(N-isopropylacrylamide)[P(NIPAAm)]and Poly(methacr-ylic acid)[P(MAA)]homopolymers and P(NIPAAm-co-MAA)random copolymers were synthesized based on NIPAAm and MAA using 4,4-Bis-(methacryloylamino)azobenzene (BMAAB)as a cross-linker.The swelling behavior of these hydrogels in different pH buffer solu-tions was studied.The influential factors of the gels including composition of NIPAAm and MAA, pH and temperature upon swelling behavior were investigated.The obtained gels not only hold pH and thermometrical sensitivity,but also take on enzymatic sensitivity due to the cross-linker could be degraded by enzymes of colon.Swelling equilibrium degree of copolymers was very low in acidic medium,which could avoid drug releasing due to biggish swelling of carrier in stomach.Hydrogels would partly swell owing to higher pH value in small intestine.When arrived in colon,hydrogels completely swelled,meanwhile,azoenzymes located would degrade azo-bonds of polymeric network and then drug released in colon.
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