论文部分内容阅读
妇女绝经后雌激素水平降低,可引起失骨加速,绝经后的妇女由于长期骨质疏松发生骨折的危险性增加。雌激素不足性失骨是由于骨吸收增加并伴有少量骨形成增加所致,当恢复雌激素水平则骨吸收和骨形成两者均被抑制,继而停止失骨。雌激素抑制骨吸收是直接对骨的作用,然而近年来通过体外研究发现降低17β-雌二醇(E_2)可抑制借助破骨细胞的骨吸收。虽然E_2降低对骨吸收和骨形成的作用有报道,但在妊娠期血液中E_2浓度对骨的作用了解还不多,本文研究应用大剂量E_2观察对骨形成和骨吸收的生物化学和组织形态学的影响。
Women’s postmenopausal estrogen levels lower, can cause accelerated bone loss, postmenopausal women due to long-term osteoporosis fracture risk increases. Estrogen-deficient bone loss is due to increased bone resorption with a small increase in bone formation, while resumption of estrogen levels inhibits both bone resorption and bone formation, which in turn halts bone loss. Estrogen inhibits bone resorption is a direct role in the bone, however, in recent years by in vitro studies found that 17β-estradiol (E_2) inhibition of bone resorption by osteoclasts. Although the effect of E_2 reduction on bone resorption and bone formation has been reported, the effect of E_2 concentration on the bone in pregnancy is poorly understood. In this paper, the biochemical and histological changes of bone formation and bone resorption were observed with high dose of E_2 The impact of learning.