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目的探讨结肠癌肝转移肝动脉置管化疗的临床意义方法 163例结肠癌肝转移患者随机分为两组,观察组82例行手术治疗,术中无论能否切除肝脏转移瘤,均行肝动脉置管并给予肝动脉化疗;对照组81例采取全身化疗和(或)手术治疗。化疗方案均采用FOLFOX4方案,并对可能影响经肝动脉置管化疗治疗疗效的因素行Cox回归多因素分析。结果肝动脉置管化疗组中为生存期(MS)、累计生存率、总有效率(CR+PR)、副作用耐受率均较对照组明显提高。结论结肠癌肝转移肝动脉置管化疗可明显提高患者的疗效,Cox回归多因素分析结果显示:肿瘤的分化程度、肝转移瘤为单发或多发、肿瘤能否切除,肿瘤局部的血供,是否伴发门静脉癌栓和疗效密切相关,有统计学意义。
Objective To investigate the clinical significance of transcatheter arterial chemoembolization in patients with hepatic metastasis of colon cancer Methods 163 patients with liver metastases from colon cancer were randomly divided into two groups. 82 patients in the observation group underwent surgical treatment. All patients underwent hepatic artery resection without hepatic metastases, The patients in control group received systemic chemotherapy and / or surgical treatment. Chemotherapy regimens used FOLFOX4 regimen, and Cox regression multivariate analysis of factors that may affect the efficacy of hepatic artery catheterization chemotherapy. Results The survival rate, cumulative survival rate, total effective rate (CR + PR) and side-effect tolerance rate of hepatic artery catheterized chemotherapy group were significantly higher than those of the control group. Conclusions The hepatic artery transcatheter hepatic metastasis of colorectal carcinoma can obviously improve the curative effect of patients. Cox regression multivariate analysis showed that the degree of tumor differentiation, single or multiple metastasis of liver tumor, tumor resection, local blood supply of tumor, Whether associated with portal vein tumor thrombus and efficacy are closely related, statistically significant.