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目的探讨尿中微量蛋白和N-乙酰-β-D-氨基葡萄糖苷酶(NAG)的检测对儿童过敏性紫癜肾炎的意义。方法根据尿常规结果将过敏性紫癜患儿分为过敏性紫癜(HSP)组和过敏性紫癜肾炎(HSPN)组,同时选取健康儿童为对照组。比较各组尿中m Alb、α_1-MG、β_2-MG、TRf、Ig G和NAG的水平。结果 HSPN组中尿m Alb、α_1-MG、β_2-MG、TRf、NAG和Ig G的含量均明显高于HSP组和对照组,差异有统计学意义(P<0.05);HSP组中尿m Alb、α_1-MG、β_2-MG、TRf和NAG的含量均高于对照组,差异有统计学意义(P<0.05);Ig G含量与对照组比较,差异无统计意义(P>0.05)。HSP组中尿中微量蛋白和NAG联合检测阳性率为77.8%,明显高于各单项检测的阳性率,差异均有统计学意义(P<0.05)。结论联合检测尿中微量蛋白和NAG的水平可较好的反映过敏性紫癜患儿的早期肾损伤。
Objective To investigate the significance of urine microalbumin and N-acetyl-β-D-glucosaminidase (NAG) in children with Henoch-Schonlein purpura nephritis. Methods The children with Henoch-Schonlein purpura were divided into HSP and HSPN groups according to the results of routine urine test. At the same time, healthy children were selected as the control group. The levels of m Alb, α 1-MG, β 2-MG, TRf, Ig G and NAG in the urine of each group were compared. Results The levels of urinary m Alb, α 1-MG, β 2-MG, TRf, NAG and Ig G in HSPN group were significantly higher than those in HSP group and control group (P <0.05) The contents of Alb, α_1-MG, β_2-MG, TRf and NAG were all higher than those in the control group (P <0.05). There was no significant difference in Ig G content between the two groups (P> 0.05). The positive rate of urinary trace protein and NAG in HSP group was 77.8%, which was significantly higher than the positive rate of each single test, the difference was statistically significant (P <0.05). Conclusion The combined detection of urinary microalbumin and NAG levels can better reflect the early renal damage in children with Henoch-Schonlein purpura.