论文部分内容阅读
目的 探讨农村成年居民幽门螺杆菌（Ｈｐ） 感染情况及其与血清胃蛋白酶原Ⅰ（ＰＧⅠ） 、胃蛋白酶原Ⅱ（ＰＧⅡ） 和胃泌素（ＧＡＳ） 水平的关系。方法 以ＥＬＩＳＡ 方法对赞皇县１ ５０４ 名３０岁以上居民血清Ｈｐ 抗体进行了检测，同时以放射免疫学方法对该组调查对象血清ＰＧⅠ、ＰＧⅡ、ＰＧⅠ／ＰＧⅡ比值和ＧＡＳ水平进行了定量分析。结果 赞皇县农村成年居民血清Ｈｐ 抗体阳性率为６６．４％ ，在性别之间阳性率差异无显著性。在不同年龄组的居民中，３０ ～５０ 岁和７０ 岁以上组血清Ｈｐ 抗体阳性率有增高趋势，但统计学意义不明显。胃癌高发区和相对低发区居民血清Ｈｐ 抗体阳性率差异不明显。血清Ｈｐ ＩｇＧ抗体阳性居民血清ＰＧⅠ、ＰＧⅡ和ＧＡＳ水平（６２ ．３μｇ／Ｌ，１５ ．４５μｇ／Ｌ，７４．００ｐｇ／ｍｌ） 均明显高于ＨｐＩｇＧ抗体阴性者（４２ ．１μｇ／Ｌ，６ ．４０μｇ／Ｌ，６６．００ｐｇ／ｍｌ） ，Ｐ＜ ０．００５ ，而血清ＰＧⅠ／ＰＧⅡ比值则显著低于后者（４．０∶６．６ ，Ｐ＜ ０．００５） 。结论 赞皇县大部分农村成年居民有Ｈｐ 感染；Ｈｐ 感染可影响血清ＰＧ和ＧＡＳ水平。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection and the levels of serum pepsinogen Ⅰ (PG Ⅰ), pepsino Ⅱ (PG Ⅱ) and gastrin (GAS) in rural residents. Methods Serum Hp antibody was detected by ELISA in 1 504 residents over the age of 30 in Zanhuang County. Meanwhile, the levels of serum PGⅠ, PGⅡ, PGⅠ / PGⅡ and GAS were quantitatively analyzed by radioimmunoassay. Results The positive rate of serum Hp antibody in rural residents in Zanhuang County was 66.4%, with no significant difference in the positive rates of gender. Among residents of different age groups, the positive rate of serum Hp antibody in 30 ~ 50 years old group and 70 years old group increased, but the statistical significance was not obvious. There was no significant difference in the positive rate of serum Hp antibody among residents with high incidence of gastric cancer and relatively low incidence of gastric cancer. Serum levels of PGⅠ, PGⅡ and GAS in serum of Hp IgG positive residents (62.3μg / L, 15.45μg / L, 74.00pg / ml) were significantly higher than those of HpIgG negative (42.1μg / L, /L,66.00pg/ml), P <0.005, while the serum PGI / PGII ratio was significantly lower than the latter (4.0: 6.6, P <0.005). Conclusion Most rural adults in Zanhuang County have Hp infection; Hp infection can affect serum PG and GAS levels.