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电刺激麻醉家免延髓头端腹外侧区(rVLM)能诱发心外膜电图ST段明显抬高。刺激腓深神经能抑制这种反应。P5平面横断脑干、双侧电解损毁中脑中央灰质腹侧部(vPAG)或在双侧rVLM微量注射脑啡肽抗体后,均能明显减弱腓深神经的抑制作用。以上结果提示腓深神经能够抑制由rVLM诱发的心肌缺血反应。腓深神经的这种抑制效应可能有赖于中脑头端以上某些区域脑结构的完整,vPAG可能是这种抑制效应的中枢环节之一,延髓水平的脑啡肽可能参与这种抑制过程。
Electro-stimulation anesthesia rostral ventrolateral medulla (rVLM) can induce epicardial electrocardiogram ST segment was significantly elevated. Stimulation of the deep peroneal nerve can inhibit this response. P5 planar transected brain stem, bilateral electrolytic destruction of central ventral midbrain gray matter (vPAG) or bilateral rVLM microinjection of enkephalin antibody, can significantly reduce the inhibitory effect of the deep peroneal nerve. The above results suggest that the deep peroneal nerve can inhibit the myocardial ischemia response induced by rVLM. The inhibitory effect of the deep peroneal nerve may depend on the integrity of the brain structure in some areas above the mid-head and head end. VPAG may be one of the central components of this inhibitory effect. Enkephalin level of enkephalin may be involved in this process.