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１２例原发甲状腺恶性淋巴瘤（ＴＬ），其中８例为老年妇女。８例中观察到淋巴上皮病损，有７例看到残余甲状腺组织呈淋巴细胞甲状腺炎（ＬＴ）样变。本组有２例为甲状腺边缘带Ｂ细胞淋巴瘤。免疫组化示１０例为Ｂ细胞性，２例为Ｔ细胞性。分析表明：ＴＬ可能与ＬＴ时的淋巴组织增生有关，部分ＴＬ可从滤泡旁Ｂ细胞起源。诊断ＴＬ的指标应包括：甲状腺正常结构破坏；异型淋巴细胞浸润；免疫组化标记ＬＣＡ阳性，Ｋｅｒ、ＴＧ及Ｃａｌｃｉｔｏｎｉｎ阴性。
Twelve primary thyroid malignant lymphomas (TL), of which 8 were elderly women. Lymphoepithelial lesions were observed in 8 cases, and residual thyroid tissue was observed in 7 cases of lymphocytic thyroiditis (LT). There were 2 cases of thyroid marginal B-cell lymphoma in this group. Immunohistochemistry showed 10 cases of B-cell and 2 cases of T-cell. Analysis shows that TL may be associated with lymphoid hyperplasia at LT, and partial TL may originate from parafollicular B cells. The indicators for the diagnosis of TL should include: normal structural destruction of the thyroid gland; infiltrative lymphocyte infiltration; positive immunohistochemical marker for LCA; negative for Ker, TG, and calcitonin.