噻吗心安(Timolol)是一种强有力的β肾上腺素能受体阻滞剂,没有膜稳定作用,亲脂性低于心得安。本文通过噻吗心安和安慰剂对冠状动脉旁路术后快速室上性心律失常预防作用的比较,来估价噻吗心安的疗效和安全性。方法:41例作选择性冠状动脉旁路术患者,男性34例,女性7例,年龄35～72岁(平均55岁)。原服用各种β受体阻滞剂者,均于术前12小时停服,对7例服用萘羟心安者于术前20小时停药。术前24小时所有病人均作24小时连续心电图记录。术后采 Timolol is a potent beta-adrenergic receptor blocker with no membrane-stabilizing effects and less lipophilicity than propranolol. This article through the timolol and placebo on the prevention of rapid supraventricular arrhythmia after coronary bypass compared to evaluate the efficacy and safety of timolol. METHODS: Totally 41 patients undergoing selective coronary artery bypass grafting were 34 males and 7 females, aged 35-72 years (mean, 55 years). The original taking a variety of β-blockers were stopped 12 hours before surgery, on the 7 cases of taking naphthalene hypocephaly 20 hours before surgery withdrawal. 24 hours before surgery, all patients were recorded 24 hours continuous ECG. Postoperative mining