采用放射免疫法检测了31例偏头痛发作期和其中的14例缓解期患者血清β_2-微球蛋白(Sβ_2-MG)浓度。结果偏头痛发作期Sβ_2-MG均值明显高于缓解期和对照组(P<0.05),缓解期Sβ_2-MG均值与对照组无明显差异(P>0.05)。典型偏头痛与普通型偏头痛患者间Sβ_2-MG均值无明显差异。认为偏头痛的发作可能有免疫机制参与。 The concentrations of serum β_2-microglobulin (Sβ_2-MG) in 31 patients with migraine and 14 patients with remission were detected by radioimmunoassay. Results The mean Sβ_2-MG in migraine attacks was significantly higher than that in remission and control groups (P <0.05). There was no significant difference in Sβ_2-MG between remission and controls (P> 0.05). There was no significant difference in mean Sβ_2-MG between typical migraine and general migraine. It is thought that the onset of migraine may have immune mechanisms involved.