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目的:为了解碱性纤维母细胞生长因子(bFGF)与血管瘤及血管畸形的关系。方法:采用免疫组织化学方法,对86例血管瘤和28例血管畸形组织切片进行 bFGF 表达的测定。结果:bFGF 在血管瘤中高表达,而在血管畸形中低表达(P<0.01)。在血管瘤中 bFGF 的表达与其内皮细胞的增生程度有关。内皮细胞增生愈强,其 bFGF 的表达愈高(P<0.01)。结论:提示 bFGF 与血管瘤的增生及退化有关,而与血管畸形无明显关系。
Objective: To investigate the relationship between basic fibroblast growth factor (bFGF) and hemangiomas and vascular malformations. Methods: Immunohistochemistry was used to determine the bFGF expression in 86 hemangiomas and 28 vascular malformations. Results: bFGF was highly expressed in hemangiomas and was low in vascular malformations (P <0.01). The expression of bFGF in hemangiomas is related to the degree of proliferation of endothelial cells. The stronger the endothelial cell proliferation, the higher the expression of bFGF (P <0.01). Conclusion: The results suggest that bFGF is associated with proliferation and degeneration of hemangiomas, but not with vascular malformations.