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应用免疫组化LSAB法测定33例胰腺癌及8例正常胰腺组织中rasP21的表达。结果表明:33例胰腺癌中20例(60.6%)P21有过度表达,正常胰腺组织全部为阴性。P21过度表达与胰腺癌的分化程度及浸润程度密切相关(P<0.05)。P21过度表达与病人二年生存率呈负相关性,统计学上检验有显著性。检测rasP21对正确评价胰腺癌的预后有一定的指导意义。
The expression of rasP21 in 33 cases of pancreatic cancer and 8 cases of normal pancreas was determined by immunohistochemical LSAB method. The results showed that P21 was overexpressed in 20 (60.6%) of 33 pancreatic cancers, and all normal pancreas tissues were negative. The overexpression of P21 was closely related to the degree of differentiation and infiltration of pancreatic cancer (P<0.05). There was a negative correlation between P21 overexpression and the patient’s two-year survival rate, which was statistically significant. The detection of rasP21 has a certain guiding significance for the correct evaluation of the prognosis of pancreatic cancer.