【摘 要】
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The incidence of venous thromboembolism(VTE)in cancer patients is 4-7 times higher than that in the general population.VTE is a common complication in clinical practice,and is the second leading cause of death in cancer patients,severely affects the progn
【机 构】
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Cancer Center The First Hospital of Jilin University,Changchun,130021,China
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The incidence of venous thromboembolism(VTE)in cancer patients is 4-7 times higher than that in the general population.VTE is a common complication in clinical practice,and is the second leading cause of death in cancer patients,severely affects the prognosis of cancer patients.Traditional chemotherapy can result in higher incidence of VTE in cancer patients,a new class of treatments,immune checkpoint inhibitors(ICIs),can reduce the immune escape of tumors and have greatly improved patient survival,become a hot issue at present.However,recent reports of high rate of VTE have raised concerns about these agents,suggests that VTE was a new type of toxicity associated with these immunotherapies.In order to make a preliminary exploration,we analyzed the results of 14 retrospective studies and two phase Ⅱ clinical trials,and herein discuss the incidence of VTE in patients receiving ICIs,as well as the postulated mechanisms and risk factors for VTE.We also analyzed the effects of these VTE on the prognosis of patients receiving ICIs and evaluated the predictive value of the Khorana score to evaluate the adverse reaction to ICIs.
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