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选择具有高中和活性和血凝抑制活性,且对肾综合征出血热病毒(HFRSV)感染乳鼠具有良好保护作用的抗-HFRSVMcAb腹水,经辛酸-硫酸铵沉淀法纯化成IgG。在纯度鉴定、免疫学活性测定及各种安全性试验合格的基础上,首次试用于3例HFRS患者的治疗。结果表明,使用安全,疗效良好。随访观察11个月,无异常反应。
Anti-HFRSVMcAb ascites with high school activity and hemagglutination inhibition activity and good protection against neonatal Hemorrhagic Fever with Renal Syndrome (HFRSV) infection was selected and purified by caprylate-ammonium sulfate precipitation. On the basis of purity identification, immunological activity determination and all kinds of safety tests, it was first tested in 3 HFRS patients. The results show that the use of safe, good effect. Follow-up observation of 11 months, no abnormal reaction.