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目的:评价抗菌药物不同时段使用对剖宫产术后患者预防感染的疗效。方法:选取2013年1月—2014年6月行剖宫产孕妇150例,将其随机分为A组、B组和C组,每组50例;A组孕妇于术前2 h给予快速静脉滴注头孢唑啉1.0 g,B组孕妇于术前30 min给予快速静脉滴注头孢唑啉1.0 g,C组孕妇于术后给予静脉滴注头孢唑啉1.0 g,均为每日2次给药,用药2 d;所有孕妇其他时期均未接受抗菌药物治疗;比较3组患者平均血浆中超敏C反应蛋白(CRP)水平值、白细胞计数值、术后3 d最高体温及术后感染的发生情况。结果:3组孕妇术后血浆中CRP水平值和白细胞计数值均高于术前,B组孕妇资料与A组和C组比较,B组术后血浆CRP水平值和白细胞计数值均下降,术后3 d体温下降;A组产妇术后血浆中CRP水平值、白细胞计数值和术后3 d体温均低于C组(P<0.05);B组产妇术后产褥感染、切口感染、宫腔感染、泌尿系统感染、盆腹腔感染和术后感染的总发生率分别低于A组和C组,A组产妇术后感染的发生率亦低于C组(P<0.05)。结论:剖宫产术前给药优于术后给药,术前给药更有效地预防剖宫产术后感染的发生,其中以术前30 min给药效果最佳。
OBJECTIVE: To evaluate the efficacy of antibacterials for preventing infection after cesarean section in different periods. Methods: A total of 150 pregnant women undergoing cesarean section were selected from January 2013 to June 2014. They were randomly divided into group A, group B and group C, with 50 cases in each group. A group of pregnant women given fast venous Instillation of cefazolin 1.0 g, B group of pregnant women given intravenous infusion of cefazolin 1.0 g 30 min before the operation, C group of pregnant women given intravenous cefazolin 1.0 g, were given twice daily Medicine and medication for 2 days. All the pregnant women were not treated with antibiotics in other periods. The mean plasma CRP level, white blood cell count, the highest body temperature after 3 days and postoperative infection were compared among the three groups Happening. Results: The postoperative plasma levels of CRP and leucocyte count were significantly higher in the three groups than those in the preoperative group. The data of pregnant women in group B were significantly lower than those in group A and C (P <0.05) After 3 days, the body temperature decreased; Group A maternal postoperative postoperative plasma levels of CRP, white blood cell count and body temperature after 3 d were lower than the C group (P <0.05); B group puerperal infection, incision infection, The total incidence of cavity infection, urinary tract infection, pelvic infection and postoperative infection were lower than those in group A and group C, respectively. The incidence of postoperative infection in group A was also lower than that in group C (P <0.05). Conclusion: Preoperative cesarean delivery is superior to postoperative administration, and preoperative administration is more effective in preventing postoperative infection of cesarean section. The best effect is given 30 min before operation.