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1 A New Therapeutic Agent for Radiation Synovectomy: Preparation of 166Ho-EDTMP-HA Bai Hongsheng Jin Xiaohai Du Jin Wang Fan Chen Daming Fan Hongqiang Cheng Zhen In order to treat the patient with inflammatory synovial disease, HA particle is labeled with 166Ho by EDTMP under the condition of pH6.0-8.0 and vibration time 15 min, its labeling efficiency is more than 98%, the size of particle is mainly in the range of 2-5 μm. The absorbed capacity is 5 mg Ho per 1g HA. Study on stability of 166Ho-EDTMP-HA in vitro shows that loss of 166Ho is less than 2% for166Ho-EDTMP-HA incubated 72 h in the 0.9% saline and 1% BSA solution at 37 ℃ .Biodistribution in vivo and extra articular leakage are investigated following injection of 166Ho-EDTMP-HA into knee of normal rabbits. The experimental results show that the extra leakage of 166Ho-EDTMP-HA is 0.32% at 48 h post-injection, most of 166Ho radioactivity leaked from the knee joint is excreted in the urine. 99% of 166Ho radioactivity is retained in the knee joint of rabbits. Thereby 166Ho-EDTMP-HA, as a new therapeutical agent of radiation synovectomy, had a value of further clinical study.
1 A New Therapeutic Agent for Radiation Synovectomy: Preparation of 166Ho-EDTMP-HA Bai Hongsheng Jin Xiaohai Du Jin Wang Fan Chen Daming Fan Hongqiang Cheng Zhen In order to treat the patient with inflammatory synovial disease, HA particle is labeled with 166Ho by EDTMP under the condition of pH 6.0-8.0 and vibration time 15 min, its labeling efficiency is more than 98%, the size of particle is mainly in the range of 2-5 μm. on stability of 166Ho-EDTMP-HA in vitro shows that the loss of 166Ho is less than 2% for166Ho-EDTMP-HA incubated for 72 h in the 0.9% saline and 1% BSA solution at 37 ° C. Biodistribution in vivo and extra articular leakage are The following experimental of injection of 166Ho-EDTMP-HA into knee of normal rabbits. The experimental results show that the extra leakage of 166Ho-EDTMP-HA is 0.32% at 48 h post-injection, most of 166Ho radioactivity leaked from the knee joint is excreted in the urine. 99% of 166Ho radioactivity is retained in the knee joint of rabbits. 166Ho-EDTMP-HA, as a new therapeutical agent of radiation synovectomy, had a value of further clinical study.