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目的探讨基因重组和尿卵泡刺激素在体外受精(IVF)和卵胞浆内单精子注射(ICSI)的妊娠结局。方法在促性腺激素释放激素激动剂(GnRHa)长或短方案下,分别应用尿卵泡刺激素(uFSH)、高纯度尿卵泡刺激素(hpFSH)和基因重组卵泡刺激素(rFSH)促排卵,回顾性分析1049例实施IVF和ICSI的治疗周期。结果无论在GnRHa长或短方案中,uFSH组和hpFSH组ICSI的受精率较IVF显著降低(P<0.0001),但在rFSH组两者无明显差异;而且各组之间IVF和ICSI的种植率或妊娠率亦无统计学差异。结论在IVF和ICSI周期治疗中,uFSH、hpFSH与rFSH具有等同的胚胎种植率和临床妊娠率。
Objective To investigate the pregnancy outcome of gene recombination and follicle stimulating hormone in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Methods Using ovarian follicle-stimulating hormone (uFSH), high-purity urofollicular follicle stimulating hormone (hpFSH) and recombinant human follicle-stimulating hormone (rFSH) to induce ovulation under the long or short gnRHa regimen, Sex analysis 1049 cases of the implementation of IVF and ICSI treatment cycle. Results The fertilization rates of ICSI in uFSH group and hpFSH group were significantly lower than those in IVF group (P <0.0001), but there was no significant difference between the two groups in rFSH group in either long or short GnRHa regimen. IVF and ICSI implantation rates Or pregnancy rate nor statistical difference. Conclusions During the IVF and ICSI cycles, uFSH, hpFSH and rFSH have the same rate of embryo implantation and clinical pregnancy.