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旨在研究泻水扶正剂治疗心力衰竭的作用机理。采用泻水扶正剂对心力衰竭模型兔灌胃给药作为治疗组,与空白组、地戈辛组、模型组对照,进行了较为系统的实验研究,结果表明:①泻水扶正剂能改善心衰兔的一般情况;②升高实验兔血浆中环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)的含量;③升高实验兔血浆中心钠素(ANP)的含量。揭示泻水扶正剂治疗心力衰竭的机理在于:提高心钠素和环磷酸腺苷、环磷酸鸟苷的血浆浓度;地戈辛样强心利尿作用。
The purpose of this study was to study the mechanism of treatment of heart failure with diarrhea and righting agent. The diarrhoeic agent was used to intragastric administration of heart failure model rabbits as a treatment group. Compared with the blank group, digoxin group and model group, a systematic experiment was conducted. The results showed that: 1 diarrhea water centering agent can improve the heart The general condition of rabbits was reduced; the content of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) was increased in 2 rabbits; and the content of plasma central atrial natriuretic peptide (ANP) was increased in 3 rabbits. The mechanism of treatment of heart failure with diarrhoeal righting agent is to increase plasma concentrations of atrial natriuretic peptide, cyclic adenosine monophosphate, and cyclic guanosine monophosphate, and digoxin-like cardiac diuresis.