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作者应用术前大剂量放射治疗和手术综合治疗喉和喉咽部晚期癌,经准确的统计学分析及14年观察结果,3年和5年存活率都比以前有一定提高。作者介绍的综合治疗分三个阶段:一、用钴~(60)远距离照射,剂量5500r,时间5—6周。二、休整期:恢复放射反应(3—6周)。三、全喉或患侧半喉切除,患侧或双侧颈廊清术。自1958—1972年,共治64例(35—79岁;男53、女11),按国际分期标准Ⅱ期20例、Ⅲ期12例、Ⅳ期32例。3年及5年存活率分别为77％和59％。并发症发生率与术前不作放射治疗的喉切除和颈廓清相同,没有因并发症而死亡者。
The author used preoperative high-dose radiation therapy and surgery to treat advanced laryngeal and laryngopharyngeal cancer. Accurate statistical analysis and 14-year observations showed that the 3-year and 5-year survival rates were somewhat higher than before. The comprehensive treatment presented by the author was divided into three phases: First, long-distance irradiation with cobalt-(60), dose 5500r, time 5-6 weeks. Second, rest period: restore radiation response (3-6 weeks). Third, full laryngeal or ipsilateral hemi-laryngectomy, ipsilateral or bilateral cervical excision. From 1958 to 1972, a total of 64 cases (35-79 years old; 53 males and 11 females) were treated. According to the international staging criteria, 20 cases were in stage II, 12 cases in stage III, and 32 cases in stage IV. The three-year and five-year survival rates were 77% and 59%, respectively. The incidence of complications was the same as that of laryngectomy and neck dissection without preoperative radiotherapy. There was no death from complications.