尿毒症患者存在着凝血与纤溶系统的异常改变 ,血液透析可以使这种变化更加明显。高凝状态及随后发生的纤溶亢进可以降低维持性血液透析患者的透析质量 ,对患者的生存质量及长期存活产生影响。本文就这一改变的发生机制、研究现状、对患者的影响、临床指标 ,及改善措施进行综述 Uremic patients have abnormal changes in the coagulation and fibrinolysis system, and hemodialysis can make this change even more pronounced. Hypercoagulable state and subsequent hyperfibrinolysis can reduce the quality of dialysis patients with maintenance hemodialysis patients, the quality of life and long-term survival of patients have an impact. This article reviews the mechanism of this change, the current status of the study, the impact on patients, clinical indicators, and improvement measures