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整合素αVβ3作为整合素家族中的重要成员,介导了细胞和细胞外基质、细胞和细胞之间的相互黏附,具有调控细胞增殖、分化、细胞形态和迁移等多种功能,在肿瘤血管生成的过程中发挥重要的作用。作为靶向肿瘤的受体,利用核素、核磁共振、超声波和光学等影像技术,结合靶向整合素αVβ3分子成像探针非侵入性的检测整合素αVβ3在肿瘤组织和肿瘤新生血管中的表达,具有潜在的临床应用价值,可用于临床肿瘤诊断和抗肿瘤药物的临床治疗后观察。本文主要针对现有靶向整合素αVβ3的分子探针及其影像技术作一简要综述。
As an important member of the integrin family, integrin αVβ3 mediates the adhesion between cells and extracellular matrix, cells and cells. It has various functions such as regulation of cell proliferation, differentiation, cell morphology and migration, and plays an important role in tumor angiogenesis Play an important role in the process. As a tumor-targeting receptor, non-invasive detection of integrin αVβ3 expression in tumor tissue and tumor neovascularization was performed using imaging techniques such as radionuclide, nuclear magnetic resonance, ultrasound and optics, in combination with targeted integrin αVβ3 molecular imaging probes , Has potential clinical value, can be used for clinical tumor diagnosis and anti-cancer drugs after clinical observation. This review focuses on the current molecular probes targeting integrin αVβ3 and its imaging technology.