论文部分内容阅读
作为组胺H_2受体拮抗剂,继西咪替丁、雷尼替丁之后,又出现了Famotidine(结构式见本刊1984,5(6):325) 化学名:3-[[〔2-[(二氨基甲叉)氨基〕-4-噻唑基〕甲基〕硫代]-N~2-氨磺酰丙脒。本品具有很强的胃酸分泌抑制作用,根据动物实验,认为其作用为西咪替丁的30倍以上,持续时间为西咪替丁的1.3倍。无抗雄激素作用及抑制药物代谢酶的作用。口服20mg,每日2次最为适宜。稻垣等对胃溃疡17例、十二指肠溃疡2例、胃及十二指肠溃疡1例,共20例使用了本品,口服8周,每日2次(早饭后、晚睡前),
As a histamine H 2 receptor antagonist, followed by cimetidine and ranitidine, Famotidine appeared again (structural formula: 1984,5 (6): 325) chemical name: 3 - [[[2- (Diaminomethane) amino] -4-thiazolyl] methyl] thio] -N ~ 2-sulfamoylpropionamidine. This product has a strong inhibition of gastric acid secretion, according to animal experiments, that the role of cimetidine 30 times more than the duration of cimetidine 1.3 times. No anti-androgen effect and inhibit the role of drug-metabolizing enzymes. Oral 20mg, 2 times a day most appropriate. Inagaki and other gastric ulcer in 17 cases, 2 cases of duodenal ulcer, stomach and duodenal ulcer in 1 case, a total of 20 cases of the FDA, oral 8 weeks, 2 times a day (after breakfast, before going to bed) ,