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目的:观察米索前列醇预防产后出血的临床效果。方法:通过分析我院2010年1月-2012年12月三年共收入院产妇2913例,经诊断将196例经阴道分娩的具有出血高危因素的产妇随机分成米索+缩宫素组105例,缩宫素组91例,两组给药时间均为胎儿娩出后,米索+缩宫素组在胎儿娩出后立即予静脉滴注缩宫素20U,并舌下含服米索前列醇400ug,缩宫素组在胎儿娩出后立即予静脉滴注缩宫素20U,观察两组产妇产后2小时出血量、产后出血发生率、第三产程时间以及副作用。结果:米索+缩宫素组产妇,取得良好效果,产后2h的出血量及产后出血发生率均明显少于缩宫素组的产妇,两组差异有统计学意义(P<0.01),具有可比性。。两组第三产程时间及不良反应发生率比较,差异无统计学意义(P>0.05)。结论:米索前列醇预防产后出血的效果优于缩宫素,且价格低廉,副作用较小,使用方便,值得临床推广应用。
Objective: To observe the clinical effect of misoprostol in preventing postpartum hemorrhage. Methods: By analyzing the hospital from January 2010 -2012 in three years a total of 2913 cases of hospitalized women, the diagnosis of 196 cases of vaginal delivery of bleeding risk factors of women were randomly divided into misoprostol group 105 cases , Oxytocin group of 91 cases, the two groups were administered after delivery of the fetus, misoprostol oxytocin group immediately after the delivery of the fetus to oxytocin intravenously 20U, and sublingual misoprostol 400ug , Oxytocin group immediately after delivery of the fetus to oxytocin intravenously 20U, two groups of postpartum 2 hours postpartum hemorrhage, postpartum hemorrhage, the third stage of labor time and side effects. Results: The patients in the misoprostol + oxytocin group achieved good results. The bleeding volume and the incidence of postpartum hemorrhage in 2 h postpartum were significantly less than those in oxytocin group (P <0.01) Comparability. . There was no significant difference between the two groups in the time of the third stage of labor and the incidence of adverse reactions (P> 0.05). Conclusion: The effect of misoprostol in preventing postpartum hemorrhage is better than that of oxytocin, and it has the advantages of low price, less side effects and easy to use. It is worthy of clinical application.