环氧乙烷灭菌最早应用于对寄生在皮毛上的虫、菌灭菌,上世纪80年代后,随着我国一次性医疗用品的大量使用,对这些物品在进入医院前的灭菌已广泛应用环氧乙烷灭菌。近年来,在档案、文物保护系统也逐步采用此方法对纸质档案、文物进行保护性灭菌。菌害是危害书籍、档案资料等文献档案的主要自然因素之一,处理菌害的方法很多,有微波、γ射线等物理方法,也有中草药、化学气体熏蒸等化学方法,其中,以熏蒸灭菌最为 Ethylene oxide sterilization was first applied to parasitic on the skin of the parasites, bacteria sterilization, the 1980s, with the large-scale use of disposable medical supplies in our country, the sterilization of these items before entering the hospital has been widespread Sterilize with ethylene oxide. In recent years, in the archives, cultural relics protection system is also gradually adopting this method of paper archives, cultural relics for protective sterilization. Germs are one of the main natural factors that endanger the archives of books, archives and other documents. There are many ways to deal with the germs, such as microwave, γ-ray and other chemical methods, as well as chemical methods such as Chinese herbal medicine and chemical gas fumigation. Among them, most