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目的探讨非典型尖锐湿疣病例乳头状瘤病毒（ＨＰＶ）感染及其临床病理特点。方法采用ＰＣＲ法检测了４０例临床疑诊为ＨＰＶ感染患者外阴湿疣组织中ＨＰＶ－ＤＮＡ类型。结果在４０例临床疑诊为尖锐湿疣的患者中，经组织病理学检查，９例确诊为尖锐湿疣；３１例为非典型尖锐湿疣，其上皮细胞轻度增生，挖空细胞不典型或无。ＨＰＶ６型阳性１３例（占４１９４％），ＨＰＶ１１型阳性１４例（占４５１６％），ＨＰＶ１６和１８型阳性５例（占１６１３％），合并淋球菌感染９例。结论非典型尖锐湿疣存在不同类型的ＨＰＶ感染，以ＨＰＶ６、１１型感染为主。ＨＰＶ－ＤＮＡ的检测有助于正确判断尖锐湿疣和假性尖锐湿疣。
Objective To investigate the clinical and pathological features of atypical condyloma acuminatum (HPV) infection. Methods The genotypes of HPV-DNA in genital warts in 40 clinically suspected cases of HPV infection were detected by PCR. Results Of the 40 clinically diagnosed patients with condyloma acuminatum, 9 cases were diagnosed as condyloma acuminatum by histopathology and 31 cases were atypical condyloma acuminatum. The epithelial cells were slightly hyperplastic and the hollowed-out cells were atypical or absent. HPV6 positive in 13 cases (4194%), HPV11 positive in 14 cases (4516%), HPV16 and 18 positive in 5 cases (1613%), gonococcal infection in 9 cases. Conclusion There are different types of HPV infection in atypical condyloma acuminatum, with infection of HPV type 6 and type 11 predominant. HPV-DNA testing can help determine the correct condyloma and pseudo-genital warts.