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目的:探讨神经节苷脂(GM1),1,6-二磷酸果糖(FDP)及复方丹参注射液等药早期联合干预对早产儿脑白质软化(PVL)的影响。方法:将2007年1月～2008年5月间在宜春市人民医院确诊的60例PVL患儿随机分为两组:对照组30例,采取对症支持等常规治疗;治疗组30例,在常规治疗的基础上加用PVL、FDP及复方丹参注射液治疗,并动态观察两组患儿头颅B超的情况,分别于矫正胎龄40周时予以NBNA评分,于1岁及2岁时评价两组干预后智力发育指数(MPI)和心理运动发育指数(PDI)及判断有无后遗症。结果:经头颅B超的动态观察,治疗组30例均较对照组好转,差异有统计学意义(P<0.05);治疗组1、2岁时MDI和PDI均高于对照组,差异有显著性(P<0.01);治疗组后遗症发生率为16.7%,对照组为46.6%,两组差异有统计学意义(P<0.05)。结论:对确诊为PVL的早产儿,在对症支持的基础上早期加用GM1、FDP及复方丹参注射液,能减轻PVL及持续性病变的发生,降低神经系统后遗症,改善预后。
Objective: To investigate the effects of early intervention such as ganglioside (GM1), fructose-1,6-diphosphate (FDP) and compound salvia miltiorrhiza injection on the white blood cell (PVL) in preterm infants. Methods: Sixty children with PVL diagnosed in Yichun People’s Hospital from January 2007 to May 2008 were randomly divided into two groups: control group (n = 30) and symptomatic supportive routine treatment (n = 30); treatment group (n = 30) Treatment with PVL, FDP and compound Salvia injection treatment, and dynamic observation of the two groups of children with cranial ultrasound B, respectively, at 40 weeks corrected gestational age to be NBNA score, at the age of 1 and 2 years to evaluate the two After the intervention, the mental development index (MPI) and psychomotor development index (PDI) and the presence or absence of sequelae were determined. Results: The dynamic changes of B-ultrasound in the treatment group were better than those in the control group (P <0.05). The MDI and PDI in the treatment group were significantly higher than those in the control group (P <0.01). The incidence of sequelae was 16.7% in the treatment group and 46.6% in the control group, with significant difference between the two groups (P <0.05). CONCLUSIONS: Early preterm infants diagnosed with PVL can be treated with GM1, FDP and Danshen injection on the basis of symptomatic support, which can reduce the incidence of PVL and persistent lesions, reduce nervous system sequelae, and improve prognosis.