目的：研究豫医无毛小鼠Ｈ 抗原系统的同源性。方法：采用近交培育２０ 代２ 月龄雌性豫医无毛小鼠皮肤异体移植法。结果：经１００ ｄ 观察，受试小鼠无急慢性排斥反应发生，移植皮片全部为永久性接受。结论：豫医无毛小鼠突变种群经２０ 代近交培育，组织相容性抗原一致，基因具有高度同源性 Objective: To study the homology of H antigen system in Yuyi hairless mice. Methods: Twenty-two-generation female Yushu hairless mice skin allograft were cultured by inbred method. Results: After 100 days of observation, there was no acute or chronic rejection in the mice. All the skin grafts were permanently accepted. CONCLUSION: The mutant population of Yuyi hairless mice was inbred by inbreeding of the 20th generation, the histocompatibility antigens were consistent and the genes were highly homologous