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盐酸左旋咪唑主要用于治疗蛔虫病和钩虫病,是一种广谱的抗线虫病药。《中国药典》1995年版二部采用提取滴定法测定其含量,误差较大。而近几年中的文献测定其含量的方法有紫外分光光度法、旋光法、阴离子表面活性剂滴定法、Nafion修饰玻碳电极法和内标高效液相色谱法等。本文采用外标高效液相色谱法测定盐酸左旋咪唑片中的盐酸左旋咪唑含量,方法简单,系统稳定性好,重复性、回收率和精密度均较好。
Levamisole hydrochloride is mainly used for the treatment of ascariasis and hookworm disease, is a broad-spectrum anti-nematode medicine. “Chinese Pharmacopoeia” 1995 edition two extraction titration determination of its content, the error is larger. In recent years, the literature to determine the content of UV spectrophotometry, optical rotation, anionic surfactant titration, Nafion modified glassy carbon electrode method and internal standard high performance liquid chromatography. In this paper, external standard high performance liquid chromatography for the determination of levamisole hydrochloride tablets levamisole content, the method is simple, the system stability, repeatability, recovery and precision are better.