对化学物是否引起机体皮肤刺激反应进行预测是化学物安全性评价或危害鉴定的重要组成部分。传统常用方法是由John Draize(1944)建立的皮肤刺激性和腐蚀性实验(Draize实验)。然而,Draize实验本身存在的许多问题,如实验评分主观性强,结果重复性差,因种属间差异而影响其结果应用于 Predicting whether a chemical causes skin irritation is an important part of chemical safety assessment or hazard identification. The traditional method used is the skin irritation and corrosivity experiment (Draize experiment) established by John Draize (1944). However, many problems with the Draize experiment itself, such as the subjective scoring of experiments, the poor reproducibility of the results, the effect of the differences between species on the results,