耳硬化症发病机制许多学说都认为是迷路骨组织代谢障碍所致。这种代谢障碍,包括镁离子。作者检查大部分耳硬化症病人存在镁离子缺乏,而且可应用镁治疗后得以矫正。作者们用动物试验研究了镁对骨迷路螺旋器、外淋巴液及其他生物组织液的影响和镁对耳硬化症病人代谢影响。第一部分为对豚鼠骨迷路的生物化学试验,常证实无迷路脱钙粘多糖含量的改变。再观察镁离子透入侧骨迷路镁的含量与对侧迷路相比较,透入侧镁增加24%,淋巴液内镁增加22%,末梢血清内增加12%。此外,对10名耳硬化症病人镁离子透入后检查外淋巴液内镁的 Many theories of the pathogenesis of otosclerosis are thought to be caused by metabolic disorders of the lost bones. This metabolic disorder, including magnesium ions. The authors examined the presence of magnesium deficiency in most otosclerosis patients and was corrected after treatment with magnesium. The authors used animal experiments to investigate the effect of magnesium on bony labyrinths, perilymph, and other biological fluids and on the metabolism of magnesium in patients with otosclerosis. The first part is a biochemical test of guinea pig labyrinth, often confirming the change of labyrinthine mucopolysaccharide. Then observe the magnesium ion penetration side of the bony magnesium content compared with contralateral labyrinth, side of the magnesium increased by 24%, magnesium in lymph increased by 22%, peripheral serum increased by 12%. In addition, 10 patients with otosclerosis after magnesium ion permeation examination of perilymph magnesium