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目的探讨肺炎支原体肺炎(MPP)患儿血清降钙素原(PCT)和C-反应蛋白(CRP)水平变化的临床意义。方法选择64例MPP患儿(MPP组)、55例细菌性肺炎患儿(细菌性肺炎组)和46例病毒性肺炎患儿(病毒性肺炎组)为研究对象,选取同期50例健康儿童(健康组)为对照组,比较各组儿童入院后24 h内血清PCT和CRP水平和阳性率。将64例MPP患儿按照病程分为急性期42例(急性期组)和恢复期22例(恢复期组),比较各组儿童血清PCT和CRP水平。结果 3组肺炎患儿血清PCT和CRP水平及阳性率均明显高于健康组儿童,差异均有统计学意义(P<0.05);细菌性肺炎患儿血清PCT和CRP水平及阳性率明显高于病毒性肺炎组和MPP组,差异均有统计学意义(P<0.05);MPP组血清PCT和CRP水平及阳性率高于病毒性肺炎组,CRP水平与病毒性肺炎组差异有统计学意义(P<0.05),而两组间血清PCT水平、PCT阳性率和CRP阳性率差异无统计学意义(P>0.05)。急性期组与恢复期组MPP患儿血清PCT和CRP水平均明显高于健康组患儿,差异均有统计学意义(P<0.05),且急性期组与恢复期组差异也有统计学意义(P<0.05)。结论血清PCT水平有助于鉴别细菌性肺炎和非细菌性肺炎,而CRP水平有助于鉴别病毒性肺炎与非病毒性肺炎,联合检测血清PCT和CRP能够更好地诊断肺炎支原体肺炎。
Objective To investigate the clinical significance of serum procalcitonin (PCT) and C-reactive protein (CRP) levels in children with Mycoplasma pneumoniae (MPP). Methods Sixty-four children with MPP (MPP group), 55 children with bacterial pneumonia (bacterial pneumonia group) and 46 children with viral pneumonia (viral pneumonia group) were selected as study objects. Fifty healthy children Healthy group) as control group. The levels of PCT and CRP and the positive rate of serum PCT in 24 h after admission were compared between the two groups. According to the course of disease, 64 MPP children were divided into acute phase (42 cases) and recovery phase (22 cases). The serum PCT and CRP levels were compared between the two groups. Results The levels of PCT and CRP in children with pneumonia were significantly higher than those in healthy children (P <0.05). The serum PCT and CRP levels and the positive rate in children with bacterial pneumonia were significantly higher than those in healthy children Viral pneumonia group and MPP group, the difference was statistically significant (P <0.05); MPP group of PCT and CRP levels and the positive rate was higher than the viral pneumonia group, CRP levels and viral pneumonia difference was statistically significant ( P <0.05). There was no significant difference in serum PCT level, PCT positive rate and CRP positive rate between the two groups (P> 0.05). The levels of serum PCT and CRP in children with MPP in acute stage and convalescent stage were significantly higher than those in healthy group (P <0.05), and the differences between acute stage group and convalescent stage group were also statistically significant ( P <0.05). Conclusions Serum PCT level is helpful to distinguish between bacterial pneumonia and non-bacterial pneumonia. CRP level is helpful in differentiating viral pneumonia from non-viral pneumonia. Combined detection of serum PCT and CRP can better diagnose Mycoplasma pneumoniae pneumonia.