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动脉粥样硬化是一种炎症性疾病.以动脉壁进行性脂质贮积,炎性细胞和平滑肌细胞浸润及细胞外基质重构为特征,是老年人血管病发病的基础。近几年,动脉粥样硬化发病中炎症因素的作用备受关注,尤其是作为关系到心脑血管疾病发展和预后的潜在蛋白标志物急性时相因子血清淀粉样蛋白A,和一种具有多重生物活性的,参与到机体各种调节的重要细胞因子白介素-6,现就对血清淀粉样蛋白A与白介素-6的生化性质、生理功能及其在致动脉粥样硬化中的作用作一综述。
Atherosclerosis is an inflammatory disease characterized by progressive lipid accumulation in the arterial wall, infiltration of inflammatory cells and smooth muscle cells, and extracellular matrix remodeling, which is the basis for the pathogenesis of vascular disease in the elderly. In recent years, the role of inflammatory factors in the pathogenesis of atherosclerosis has attracted much attention, especially as an acute phase factor related to the development and prognosis of cardiovascular and cerebrovascular diseases. Serum amyloid A, and one with multiple Biologically active interleukin-6, an important cytokine involved in various regulation of the body, now reviews the biochemical properties of serum amyloid A and interleukin-6, their physiological functions and their role in atherogenic .