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目的探讨国产缬沙坦胶囊(Valsartan Capsule,商品名:托平Tuoping)和进口缬沙坦胶囊(商品名:代文Diovan)对轻中度原发性高血压患者的降压疗效及安全性。方法采用互相对照方式。将58例轻中度原发性高血压患者随机分成2组,托平组(80mg,),代文组(80mg1次/d),疗程均4周。每2周随访BP、HR,并记录不良反应。观察服药前、服药后2周和4周的BP、HR变化,进行记录比较。结果经4周治疗,2组血压平均SBP由(153.1±11.6)mmHg分别降至(130.9±10.5)、(130.8±10.8)mmHg;DBP由(96.1±12.6)mmHg分别降至和(81.1±6.9,80.9±7.3)mmHg,2组较服药前均有显著降低(P<0.01),总有效率均为68.97%,2组服药后同期疗效无统计学差异(P>0.05);2组治疗期间均未见明显不良反应。结论托平和代文对轻中度原发性高血压具有相同降压效性,两者同样安全可靠,不良反应少,但托平价格低廉。
Objective To investigate the antihypertensive efficacy and safety of domestic Valsartan Capsule (brand name Tuoping) and imported valsartan capsules (brand name Diovan) in patients with mild to moderate essential hypertension. Methods used to control each other. 58 patients with mild to moderate essential hypertension were randomly divided into two groups, Tuopin group (80mg), Daiwen group (80mg1 times / d), the course of treatment were 4 weeks. Follow up every two weeks for BP and HR, and record the adverse reactions. The changes of BP and HR before and 2 and 4 weeks after taking the medicine were observed and compared. Results After 4 weeks of treatment, the average SBP of blood pressure decreased from (153.1 ± 11.6) mmHg to (130.9 ± 10.5) and (130.8 ± 10.8) mmHg in the two groups, and decreased from (96.1 ± 12.6) mmHg to (81.1 ± 6.9) , 80.9 ± 7.3) mmHg, both groups were significantly lower than those before treatment (P <0.01), the total effective rate was 68.97%. There was no significant difference between the two groups in the same period after treatment (P> 0.05) No obvious adverse reactions were seen. Conclusion Tuoping and Daiwen have the same antihypertensive effect on mild to moderate essential hypertension, both of which are equally safe and reliable with few adverse reactions, but the price of Toto is low.