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为了进一步证实某些药物对红细胞膜稳定(即抗溶血)作用及抑制CaM功能与药理作用之间的相关性,本文选用丹参酮Ⅱ-A磺酸钠,戊脉安,奎尼丁和莨菪类药物,测定它们对大鼠红细胞溶血及CaM功能的影响。结果表明丹参酮Ⅱ-A磺酸钠,戊脉安,奎尼丁对红细胞溶血抑制率分别为100％,71％,32％,对CaM功能的抑制分别为71.8％,63.4％,46.4％。莨菪类药物有促溶血作用,对CaM功能的抑制也极弱。我们还发现以上药物对膜上Ca~(2+)+Mg~(2+)-ATP酶的直接作用亦有类似的规律。这种相关性可能与膜表面CaM与钙离子,靶酶及药物结合区的疏水性及药物本身的相对疏水性有关。
In order to further confirm the stability of certain drugs on the erythrocyte membrane (ie, anti-hemolysis) and inhibit the relationship between CaM function and pharmacological effects, this paper selected tanshinone Ⅱ A sodium sulfates, verapamil, quinidine and scopolamine , To determine their impact on rat erythrocyte hemolysis and CaM function. The results showed that the inhibitory rates of tanshinone Ⅱ-A sulfonate, verapamil and quinidine on hemolysis of erythrocytes were 100%, 71% and 32%, respectively, and the inhibitory effects on CaM function were 71.8%, 63.4% and 46.4%, respectively. Herpes drugs have hemolysis, inhibition of CaM function is also very weak. We also found that the direct effects of the above drugs on the membrane Ca ~ (2 +) + Mg ~ (2 +) - ATPase also have similar rules. This correlation may be related to the membrane surface CaM and calcium ions, the hydrophobicity of the target enzyme and drug binding region and the relative hydrophobicity of the drug itself.