论文部分内容阅读
妥拉苏林(T)常用于治疗新生儿肺高血压,但在治疗中常伴有少尿和肾衰发生。对此尚未作过充分研究。作者在羊中对T稳态浓度的作用与生理盐水对排尿作用和长期使用导尿管时心血管系统的影响,进行了比较。实验是在同一只羊、在不同天接受对照生理盐水(C) (n=5)和T(n=6),每次观察时间约6小时。体液摄入量平均14.8ml/kg/hr,对照组与给药组无差别。对照组排尿量稳定在3.34ml/kg/hr,心血管参数无改变。相此之下,给药组的
Torapredulin (T) is commonly used to treat neonatal pulmonary hypertension, but is often accompanied by oliguria and renal failure in the treatment. This has not been fully studied. The authors compared the effect of steady-state concentrations of T in sheep with the effect of saline on urination and long-term use of catheters in the cardiovascular system. The experiment was on the same sheep and received control saline (C) (n = 5) and T (n = 6) on different days for approximately 6 hours per observation. Body fluid intake average 14.8ml / kg / hr, the control group and the administration group no difference. Urine volume in the control group stabilized at 3.34ml / kg / hr, no change in cardiovascular parameters. In the meantime, the administration group