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目的 研究脑梗塞患者１１－ 去氢－ 血栓烷Ｂ２（１１－ ＤＨ－ ＴＸＢ２） 与血栓烷Ｂ２（ＴＸＢ２） 对血小板活化程度的敏感特异性。方法 采用酶免疫法、放射免疫法检测４３ 例脑梗塞患者与对照组（１５ 例） 血浆（１１ － ＤＨ－ ＴＸＢ２）浓度，对比两者的敏感特异性，并研究脑梗塞患者１１ － ＤＨ－ ＴＸＢ２ 、ＴＸＢ２ 的改变。结果 患者组血浆１１ － ＤＨ－ＴＸＢ２ 浓度显著高于对照组（ Ｐ＜０ ．００１） ，而ＴＸＢ２ 浓度变化无显著差异（ Ｐ＞ ０．０５） ；其中发病在７２ｈ 内的患者有８１．２５ ％ 血浆１１－ ＤＨ－ ＴＸＢ２ 浓度高于对照组峰值；而ＴＸＢ２ 与对照组有相当的重叠。结论 与ＴＸＢ２ 相比，血浆１１－ ＤＨ－ ＴＸＢ２ 能更特异与敏感地反映体内血小板活化程度，急性期脑梗塞患者体内血小板高度活化。
Objective To investigate the sensitivity of 11-dehydro-thromboxane B2 (11-DH-TXB2) and thromboxane B2 (TXB2) to platelet activation in patients with cerebral infarction. Methods Enzyme immunoassay and radioimmunoassay were used to detect the plasma concentrations of 11 - DH - TXB2 in 43 cerebral infarction patients and 15 healthy volunteers. The sensitivity and specificity of 11 - DH - TXB2 were compared. , TXB2 changes. Results The level of plasma 11 - DH - TXB2 was significantly higher in patients than in controls (P <0 .001), but there was no significant difference in TXB2 concentrations (P> 0.05). The incidence of 81 11% The concentration of plasma 11-DH-TXB2 was higher than that of the control group; however, there was considerable overlap between TXB2 and the control group. Conclusions Compared with TXB2, plasma 11-DH-TXB2 can more specifically and sensitively reflect the activation of platelet in vivo. Platelet activation in patients with acute cerebral infarction is highly significant.