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目的:研究九味羌活颗粒中挥发油β-环糊精(β-CD)包合的最佳工艺。方法:采用饱和溶液法制备包合物,应用L_9(3~4)正交试验设计优选最佳包合工艺条件,以包合物收得率和挥发油转化率为指标,以β-CD与挥发油的比例、包合温度、包合时间为考察因素。结果:最佳包合工艺条件为挥发油:β-CD为1ml:10g,40℃搅拌1h。结论:正交试验优选的包合工艺合理,包合率高,工艺稳定。
Objective: To study the best technology of inclusion of β-cyclodextrin (β-CD) of volatile oil in Jiusueqianghuo granules. Methods: The inclusion complex was prepared by saturated solution method. The optimal inclusion conditions were optimized by orthogonal design of L_9 (3-4). The yield of inclusion compound and the conversion rate of volatile oil were taken as indices. The β-CD and volatile oil The proportion of inclusion temperature, inclusion time for the study of factors. Results: The optimum conditions for the inclusion of volatile oil: β-CD was 1ml: 10g, 40 ℃ for 1h. Conclusion: Orthogonal test is a suitable inclusion process with reasonable inclusion rate and process stability.